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Synthesis of 7-aza-5-deazapurine analogues via copper(i)-catalyzed hydroamination of alkynes and 1-iodoalkynes

Academic Article
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Overview

authors

  • Krasnova, L. B.
  • Hein, J. E.
  • Fokin, Valery

publication date

  • 2010

journal

  • Journal of Organic Chemistry  Journal

abstract

  • A new method for the synthesis of dihydroimidazo[1,2-a][1,3,5]triazin-4(6H)-ones via copper(I)-catalyzed hydroamination was developed. In addition, for the first time, iodoalkynes were shown to participate in the copper(I)-catalyzed intramolecular hydroamination reaction with exclusive formation of E-isomers.

subject areas

  • Alkynes
  • Amination
  • Aza Compounds
  • Catalysis
  • Copper
  • Hydrocarbons, Iodinated
  • Isomerism
  • Molecular Structure
  • Purines
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Identity

PubMed Central ID

  • PMC3025312

International Standard Serial Number (ISSN)

  • 0022-3263

Digital Object Identifier (DOI)

  • 10.1021/jo1016376

PubMed ID

  • 21105687
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Additional Document Info

start page

  • 8662

end page

  • 8665

volume

  • 75

issue

  • 24

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