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Interleukin-1 beta and tumour necrosis factor-alpha stimulate the mRNA expression of interleukin-1 receptors in mouse anterior pituitary AtT-20 cells

Academic Article
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Overview

authors

  • Bristulf, J.
  • Bartfai, Tamas

publication date

  • 1995

journal

  • Neuroscience Letters  Journal

abstract

  • The RT-PCR technique was used to study IL-1 receptor mRNA levels in AtT-20 cells. IL-1 beta increased type I IL-1 receptor mRNA levels within 1 h, with elevated levels remaining after 24 h, whereas it induced a bell-shaped alteration of type II IL-1 receptor mRNA levels, with a peak after 6 h. Tumour necrosis factor-alpha (TNF alpha) similarly up-regulated type II IL-1 receptor mRNA levels, and type I IL-1 receptor mRNAs albeit to a lesser extent than IL-1 beta. Furthermore, IL-1 beta also induced increases in TNF alpha and c-fos mRNAs. The IL-1 receptor antagonist can fully block all the above effects of IL-1 beta. Up-regulation of type II IL-1R mRNA levels in AtT-20 cells could constitute an important way to modulate IL-1 actions, since type II IL-1R is believed to antagonize IL-1 effects.

subject areas

  • Animals
  • Gene Expression
  • Interleukin-1
  • Mice
  • Pituitary Gland
  • Polymerase Chain Reaction
  • RNA, Messenger
  • Receptors, Interleukin-1
  • Time Factors
  • Transcription, Genetic
  • Tumor Necrosis Factor-alpha
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Identity

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(95)11336-u

PubMed ID

  • 7617302
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Additional Document Info

start page

  • 53

end page

  • 56

volume

  • 187

issue

  • 1

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