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Inhibition of hepatitis B virus replication during schistosoma mansoni infection in transgenic mice

Academic Article
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Overview

authors

  • McClary, H.
  • Koch, R.
  • Chisari, Francis
  • Guidotti, Luca

publication date

  • July 2000

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Although coinfection of hepatitis B virus (HBV) and Schistosoma mansoni is a frequent event in humans, little is known about the interactions between these two pathogens. S. mansoni infection induces T helper cell type 2 (Th2)-type cytokines in the liver of humans and mice. The intrahepatic induction of nitric oxide (NO) and Th1-type cytokines, such as interferon (IFN)-gamma and IFN-alpha/beta, inhibits HBV replication noncytopathically in the liver of transgenic mice. To examine whether S. mansoni infection and the accompanying induction of Th2-type cytokines could interfere with HBV replication in the liver, HBV transgenic mice were infected with S. mansoni. By 5 wk after infection, HBV replication disappeared concomitant with the intrahepatic induction of NO and Th1-type cytokines, and in the absence of Th2-type cytokines. By 6-8 wk after infection, HBV replication remained undetectable and this was associated with further induction of NO and Th1-type cytokines together with the appearance of Th2-type cytokines. The S. mansoni-dependent antiviral effect was partially blocked by genetically deleting IFN-gamma, although it was unaffected by deletion of IFN-alpha/beta. These results indicate that IFN-gamma (probably via NO) mediates most of this antiviral activity and that Th2-type cytokines do not counteract the antiviral effect of IFN-gamma. Similar events may suppress HBV replication during human S. mansoni infection.

subject areas

  • Animals
  • Hepatitis B virus
  • Interferon-gamma
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Nitric Oxide
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type II
  • Schistosomiasis mansoni
  • Virus Replication
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Research

keywords

  • Th1/Th2 cytokines
  • helminth parasites
  • infectious immunity virus
  • liver
  • transgenic/knockout
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Identity

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.192.2.289

PubMed ID

  • 10899915
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Additional Document Info

start page

  • 289

end page

  • 294

volume

  • 192

issue

  • 2

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