Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Naloxone-induced seizures in rats infected with borna disease virus

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Solbrig, M. V.
  • Koob, George
  • Lipkin, W. I.

publication date

  • April 1996

journal

  • Neurology  Journal

abstract

  • The opioid antagonist naloxone is widely used in the emergency treatment of nontraumatic coma. Although it is uncommon for serious side effects to result from administration of opiate antagonists, we report that naloxone can have epileptogenic effects in the context of encephalitis. In an experimental model of viral encephalitis, rats infected with Borna disease virus developed myoclonic, generalized clonic, or atonic seizures; behavior arrest; and staring spells when treated with naloxone. These findings suggest a novel neuropharmacologic link, through opioid peptide systems, between epilepsy and encephalitis and disclose a potential contraindication to use of opioid antagonists in nontraumatic coma.

subject areas

  • Animals
  • Borna Disease
  • Dyskinesia, Drug-Induced
  • Encephalitis, Viral
  • Male
  • Naloxone
  • Rats
  • Rats, Inbred Lew
  • Seizures
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0028-3878

PubMed ID

  • 8780117
scroll to property group menus

Additional Document Info

start page

  • 1170

end page

  • 1171

volume

  • 46

issue

  • 4

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support