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Destruction of the locus-ceruleus decreases physical signs of opiate withdrawal

Academic Article
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Overview

authors

  • Maldonado, R.
  • Koob, George

publication date

  • March 1993

journal

  • Brain Research  Journal

abstract

  • The purpose of the present study was to investigate the role of the locus coeruleus in the development of opiate dependence. Two groups of rats each were subjected to either a electrolytic lesion of the locus coeruleus or a sham lesion. All animals were implanted with an intracerebroventricular (i.c.v.) cannula, and made physically dependent by subcutaneous insertion of two 75-mg morphine (base) pellets. Abstinence was precipitated by i.c.v. administration of methylnaloxonium (31-1,000 ng) 72 h after pellet implantation. Methylnaloxonium administered intracerebroventricularly induced a withdrawal syndrome characterized by the appearance of teeth chattering, mastication, rearing, wet dog shakes, jumping, piloerection, hyperactivity, ptosis and eye twitch. Withdrawal observed in the electrolytic lesion groups was less severe than in sham group. The presence of mastication, rearing, piloerection, hyperactivity, ptosis and eye twitch was significantly lower. These results support the hypothesis that the locus coeruleus has an important role in the expression of the physical signs of opiate dependence.

subject areas

  • Animals
  • Blepharoptosis
  • Body Weight
  • Brain Chemistry
  • Dose-Response Relationship, Drug
  • Eye Movements
  • Injections, Intraventricular
  • Locus Coeruleus
  • Male
  • Mastication
  • Morphine
  • Morphine Dependence
  • Motor Activity
  • Naloxone
  • Norepinephrine
  • Piloerection
  • Quaternary Ammonium Compounds
  • Rats
  • Rats, Wistar
  • Substance Withdrawal Syndrome
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Research

keywords

  • ELECTROLYTICAL LESION
  • INTRACEREBROVENTRICULAR
  • LOCUS CERULEUS
  • METHYLNALOXONIUM
  • MORPHINE DEPENDENCE
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Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(93)91364-x

PubMed ID

  • 8467382
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Additional Document Info

start page

  • 128

end page

  • 138

volume

  • 605

issue

  • 1

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