recent publications

• academic article

  • Tishon, A., Lewicki, H., Andaya, A., McGavern, D., Martin, L., Oldstone, M. B. A. Cd4 t cell control primary measles virus infection of the cns: Regulation is dependent on combined activity with either cd8 t cells or with b cells: Cd4, cd8 or b cells alone are ineffective Virology  2006 347:234-245  DOI:10.1016/j.virol.2006.01.050  PMID:16529787
  • Oldstone, M. B. A., Dales, S., Tishon, A., Lewicki, H., Martin, L. A role for dual viral hits in causation of subacute sclerosing panencephalitis Journal of Experimental Medicine  2005 202:1185-1190  DOI:10.1084/jem.20051376  PMID:16260490  PMCID:PMC1350947
  • Slifka, M. K., Homann, D., Tishon, A., Pagarigan, R., Oldstone, M. B. A. Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection Journal of Clinical Investigation  2003 111:805-810  DOI:10.1172/jci200313603  PMID:12639986
  • Lewicki, H., Tishon, A., Homann, D., Mazarguil, H., Laval, F., Asensio, V. C., Campbell, I. L., DeArmond, S., Coon, B., Teng, C., Gairin, J. E., Oldstone, M. B. A. T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies Journal of Virology  2003 77:3799-3808  DOI:10.1128/jvi.77.6.3799-3808.2003  PMID:12610154
  • Smelt, S. C., Borrow, P., Kunz, S., Cao, W., Tishon, A., Lewicki, H., Campbell, K. P., Oldstone, M. B. A. Differences in affinity of binding of lymphocytic choriomeningitis virus strains to the cellular receptor alpha-dystroglycan correlate with viral tropism and disease kinetics Journal of Virology  2001 75:448-457  DOI:10.1128/jvi.75.1.448-457.2001  PMID:11119613
  • Tishon, A., LaFace, D. M., Lewicki, H., van Binnendijk, R. S., Osterhaus, A., Oldstone, M. B. A. Transgenic mice expressing human hla and cd8 molecules generate hla-restricted measles virus cytotoxic t lymphocytes of the same specificity as humans with natural measles virus infection Virology  2000 275:286-293  DOI:10.1006/viro.2000.0517  PMID:10998329
  • Oldstone, M. B. A., Lewicki, H., Thomas, D., Tishon, A., Dales, S., Patterson, J., Manchester, M., Homann, D., Naniche, D., Holz, A. Measles virus infection in a transgenic model: Virus-induced immunosuppression and central nervous system disease Cell  1999 98:629-640  DOI:10.1016/s0092-8674(00)80050-1  PMID:10490102
  • Homann, D., Tishon, A., Berger, D. P., Weigle, W. O., von Herrath, M. G., Oldstone, M. B. A. Evidence for an underlying cd4 helper and cd8 t-cell defect in b-cell-deficient mice: Failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from mu mt/mu mt mice Journal of Virology  1998 72:9208-9216  PMID:9765468  PMCID:PMC110340
  • Borrow, P., Tough, D. F., Eto, D., Tishon, A., Grewal, I. S., Sprent, J., Flavell, R. A., Oldstone, M. B. A. Cd40 ligand-mediated interactions are involved in the generation of memory cd8(+) cytotoxic t lymphocytes (ctl) but are not required for the maintenance of ctl memory following virus infection Journal of Virology  1998 72:7440-7449  PMID:9696840
  • Tishon, A., Manchester, M., Scheiflinger, F., Oldstone, M. B. A. A model of measles virus-induced immunosuppression: Enhanced susceptibility of neonatal human pbls Nature Medicine  1996 2:1250-1254  DOI:10.1038/nm1196-1250  PMID:8898755
  • Borrow, P., Tishon, A., Lee, S., Xu, J. C., Grewal, I. S., Oldstone, M. B. A., Flavell, R. A. Cd40l-deficient mice show deficits in antiviral immunity and have an impaired memory cd8(+) ctl response Journal of Experimental Medicine  1996 183:2129-2142  DOI:10.1084/jem.183.5.2129  PMID:8642323
  • Dockter, J., Evans, C. F., Tishon, A., Oldstone, M. B. A. Competitive selection in vivo by a cell for one variant over another: Implications for rna virus quasispecies in vivo Journal of Virology  1996 70:1799-1803  PMID:8627703  PMCID:PMC190006
  • Tishon, A., Lewicki, H., Rall, G., Vonherrath, M., Oldstone, M. B. A. An essential role for type-1 interferon-gamma in terminating persistent viral-infection Virology  1995 212:244-250  DOI:10.1006/viro.1995.1477  PMID:7676639
  • Lewicki, H., Tishon, A., Borrow, P., Evans, C. F., Gairin, J. E., Hahn, K. M., Jewell, D. A., Wilson, I. A., Oldstone, M. B. A. Ctl escape viral variants .1. Generation and molecular characterization Virology  1995 210:29-40  DOI:10.1006/viro.1995.1314  PMID:7793078
  • Gold, L. H., Brot, M. D., Polis, I., Schroeder, R., Tishon, A., Delatorre, J. C., Oldstone, M. B. A., Koob, G. F. Behavioral-effects of persistent lymphocytic choriomeningitis virus-infection in mice Behavioral and Neural Biology  1994 62:100-109  DOI:10.1016/s0163-1047(05)80031-7  PMID:7993301
  • Hahn, K., Debiasio, R., Tishon, A., Lewicki, H., Gairin, J. E., Larocca, G., Taylor, D. L., Oldstone, M. Antigen presentation and cytotoxic t-lymphocyte killing studied in individual, living cells Virology  1994 201:330-340  DOI:10.1006/viro.1994.1298  PMID:8184542
  • Tishon, A., Eddleston, M., Delatorre, J. C., Oldstone, M. B. A. Cytotoxic T-lymphocytes cleanse viral gene-products from individually infected neurons and lymphocytes in mice persistently infected with lymphocytic choriomeningitis virus Virology  1993 197:463-467  DOI:10.1006/viro.1993.1613  PMID:8212586
  • Tishon, A., Borrow, P., Evans, C., Oldstone, M. B. A. Virus-induced immunosuppression .1. Age at infection relates to a selective or generalized defect Virology  1993 195:397-405  DOI:10.1006/viro.1993.1389  PMID:8393233
  • Oldstone, M. B. A., Tishon, A., Eddleston, M., Delatorre, J. C., McKee, T., Whitton, J. L. Vaccination to prevent persistent viral infection Journal of Virology  1993 67:4372-4378  PMID:8510226  PMCID:PMC237809
  • Lewicki, H., McKee, T. A., Tishon, A., Salvato, M., Whitton, J. L., Oldstone, M. B. A. Novel lcmv-specific h-2k restricted ctl clones recognize internal viral gene-products and cause cns disease Journal of Neuroimmunology  1992 41:15-20  DOI:10.1016/0165-5728(92)90190-v  PMID:1281166
  • Oldstone, M. B. A., Tishon, A., Geckeler, R., Lewicki, H., Whitton, J. L. A common antiviral cytotoxic lymphocyte-t epitope for diverse major histocompatibility complex haplotypes - implications for vaccination Proceedings of the National Academy of Sciences of the United States of America  1992 89:2752-2755  DOI:10.1073/pnas.89.7.2752  PMID:1372990
  • Yanagi, Y., Tishon, A., Lewicki, H., Cubitt, B. A., Oldstone, M. B. A. Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule Journal of Virology  1992 66:2527-2531  PMID:1372370  PMCID:PMC289052
  • Tishon, A., Salmi, A., Ahmed, R., Oldstone, M. B. A. Role of viral strains and host genes in determining levels of immune-complexes in a model system - implications for hiv-infection AIDS Research and Human Retroviruses  1991 7:963-969  DOI:10.1089/aid.1991.7.963  PMID:1812945
  • Borrow, P., Tishon, A., Oldstone, M. B. A. Infection of lymphocytes by a virus that aborts cytotoxic lymphocyte-t activity and establishes persistent infection Journal of Experimental Medicine  1991 174:203-212  DOI:10.1084/jem.174.1.203  PMID:1905339
  • Oldstone, M. B. A., Tishon, A., Lewicki, H., Dyson, H. J., Feher, V. A., Assamunt, N., Wright, P. E. Mapping the anatomy of the immunodominant domain of the human immunodeficiency virus gp41 transmembrane protein: peptide conformation analysis using monoclonal antibodies and proton nuclear magnetic resonance spectroscopy Journal of Virology  1991 65:1727-1734  PMID:2002540  PMCID:PMC239977
  • Tishon, A., Oldstone, M. B. A. Perturbation of differentiated functions during viral infection in vivo. In vivo relationship of host genes and lymphocytic choriomeningitis virus to growth hormone deficiency American Journal of Pathology  1990 137:965-969  PMID:2221020  PMCID:PMC1877543
  • Oldstone, M. B. A., Tishon, A., Schwimmbeck, P. L., Shyp, S., Lewicki, H., Dyrberg, T. Cytotoxic lymphocytes-t do not control lymphocytic choriomeningitis virus-infection of bb diabetes-prone rats Journal of General Virology  1990 71:785-791  DOI:10.1099/0022-1317-71-4-785  PMID:2324708
  • Shyp, S., Tishon, A., Oldstone, M. B. A. Inhibition of diabetes in bb rats by virus-infection .2. Effect of virus-infection on the immune-response to nonviral and viral-antigens Immunology  1990 69:501-507  PMID:2335372  PMCID:PMC1385619
  • Whitton, J. L., Tishon, A., Lewicki, H., Gebhard, J., Cook, T., Salvato, M., Joly, E., Oldstone, M. B. A. Molecular analyses of a 5-amino-acid cyto-toxic lymphocyte-t (ctl) epitope - an immunodominant region which induces nonreciprocal ctl cross-reactivity Journal of Virology  1989 63:4303-4310  PMID:2476570  PMCID:PMC251046
  • Klavinskis, L. S., Tishon, A., Oldstone, M. B. A. Efficiency and effectiveness of cloned virus-specific cytotoxic T lymphocytes in vivo Journal of Immunology  1989 143:2013-2016  PMID:2476492
  • Oldstone, M. B. A., Whitton, J. L., Lewicki, H., Tishon, A. Fine dissection of a 9 amino-acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class-i-restricted h-2db cyto-toxic lymphocytes-t Journal of Experimental Medicine  1988 168:559-570  DOI:10.1084/jem.168.2.559  PMID:2457647
  • Oldstone, M. B. A., Salvato, M., Tishon, A., Lewicki, H. Virus lymphocyte interactions .3. Biologic parameters of a virus variant that fails to generate ctl and establishes persistent infection in immunocompetent hosts Virology  1988 164:507-516  DOI:10.1016/0042-6822(88)90565-x  PMID:2967012
  • Whitton, J. L., Gebhard, J. R., Lewicki, H., Tishon, A., Oldstone, M. B. A. Molecular definition of a major cyto-toxic lymphocyte-t epitope in the glycoprotein of lymphocytic choriomeningitis virus Journal of Virology  1988 62:687-695  PMID:2448497  PMCID:PMC253621
  • Tishon, A., Southern, P. J., Oldstone, M. B. A. Virus-lymphocyte interactions .2. Expression of viral sequences during the course of persistent lymphocytic choriomeningitis virus-infection and their localization to the lymphocyte-l3t4 subset Journal of Immunology  1988 140:1280-1284  PMID:2963865
  • Tishon, A., Oldstone, M. B. A. Persistent virus infection associated with chemical manifestations of diabetes. II. Role of viral strain, environmental insult, and host genetics American Journal of Pathology  1987 126:61-72  PMID:2949622  PMCID:PMC1899557
  • Oldstone, M. B. A., Ahmed, R., Buchmeier, M. J., Blount, P., Tishon, A. Perturbation of differentiated functions during viral infection in vivo. I. Relationship of lymphocytic choriomeningitis virus and host strains to growth hormone deficiency Virology  1985 142:158-174  DOI:10.1016/0042-6822(85)90430-1  PMID:2414901
  • Oldstone, M. B. A., Fujinami, R. S., Tishon, A., Finney, D., Powell, H. C., Lampert, P. W. Mapping of the major histocompatibility complex and viral-antigens on the plasma-membrane of a measles virus-infected cell Virology  1983 127:426-437  DOI:10.1016/0042-6822(83)90155-1  PMID:6575495
  • Oldstone, M. B. A., Tishon, A., Buchmeier, M. J. Virus-induced immune complex disease: genetic control of C1q binding complexes in the circulation of mice persistently infected with lymphocytic choriomeningitis virus Journal of Immunology  1983 130:912-918  PMID:6217255
  • Oldstone, M. B. A., Sinha, Y. N., Blount, P., Tishon, A., Rodriguez, M., Vonwedel, R., Lampert, P. W. Virus-induced alterations in homeostasis: alteration in differentiated functions of infected cells in vivo Science  1982 218:1125-1127  DOI:10.1126/science.7146898  PMID:7146898
  • Oldstone, M. B. A., Tishon, A., Dutko, F. J., Kennedy, S. I. T., Holland, J. J., Lampert, P. W. Does the major histocompatibility complex serve as a specific receptor for semliki forest virus Journal of Virology  1980 34:256-265  PMID:7373708  PMCID:PMC288691
  • Oldstone, M. B. A., Buchmeier, M. J., Doyle, M. V., Tishon, A. Virus-induced immune complex disease: specific anti-viral antibody and C1q binding material in the circulation during persistent lymphocytic choriomeningitis virus infection Journal of Immunology  1980 124:831-838  PMID:6444319
  • Oldstone, M. B. A., Tishon, A. Immunological injury in measles-virus infection .4. Antigenic modulation and abrogation of lymphocyte lysis of virus-infected cells Clinical Immunology and Immunopathology  1978 9:55-62  DOI:10.1016/0090-1229(78)90120-4  PMID:618410
  • Oldstone, M. B. A., Tishon, A., Moretta, L. Active thymus derived suppressor lymphocytes in human cord blood Nature  1977 269:333-335  DOI:10.1038/269333a0  PMID:302917
  • Perrin, L. H., Tishon, A., Oldstone, M. B. A. Immunological injury in measles-virus infection .3. Presence and characterization of human cytotoxic lymphocytes Journal of Immunology  1977 118:282-290  PMID:830751
  • Oldstone, M. B., Tishon, A., Chiller, J. M. Chronic virus-infection and immune responsiveness .2. Lactic-dehydrogenase virus-infection and immune-response to non-viral antigens Journal of Immunology  1974 112:370-375  PMID:4590825
  • Oldstone, M. B., Tishon, A., Chiller, J. M., Weigle, W. O., Dixon, F. J. Effect of chronic viral-infection on immune system .1. Comparison of immune responsiveness of mice chronically infected with lcm virus with that of noninfected mice Journal of Immunology  1973 110:1268-1278  PMID:4121421