Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Neuropeptide Y receptors and the inhibition of adenylate cyclase in the human frontal and temporal cortex

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Westlinddanielsson, A.
  • Unden, A.
  • Abens, J.
  • Andell, S.
  • Bartfai, Tamas

publication date

  • February 1987

journal

  • Neuroscience Letters  Journal

abstract

  • The presence of a single class of high affinity, saturable binding sites for [3H]neuropeptide Y (NPY) was demonstrated in membranes from human frontal and temporal cortex. The specific binding of [3H]NPY was sensitive to guanosine 5'-triphosphate (GTP) and guanylyl-imidodiphosphate (GMPP(NH)P; 100 microM) which lowered the total binding capacity (Bmax) value (35 +/- 2 fmol/mg in the frontal cortex and 82 +/- 3 fmol/mg in the temporal cortex) by 50%. GTP and GMPP(NH)P did not affect the dissociation constant (Kd) value which was 0.25 +/- 0.03 nM in a frontal cortex sample and 0.76 +/- 0.06 nM in the sample from the temporal cortex. The affinity and GTP sensitivity of the [3H]NPY binding to human brain membranes parallels that found in the rat brain. It was demonstrated that occupancy of NPY receptors by NPY (1 microM) inhibits the basal and forskolin (10 microM)-stimulated adenylate cyclase activity by 18-30% in a crude membrane preparation from human frontal cortex.

subject areas

  • Adenosine Triphosphate
  • Adenylyl Cyclases
  • Adenylyl Imidodiphosphate
  • Adult
  • Female
  • Frontal Lobe
  • Guanosine Triphosphate
  • Guanylyl Imidodiphosphate
  • Humans
  • Male
  • Middle Aged
  • Neuropeptide Y
  • Receptors, Neuropeptide Y
  • Receptors, Neurotransmitter
  • Temporal Lobe
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(87)90156-x

PubMed ID

  • 3033554
scroll to property group menus

Additional Document Info

start page

  • 237

end page

  • 242

volume

  • 74

issue

  • 2

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support