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Inhibition by noncompetitive nmda receptor antagonists of apomorphine-induced climbing behavior in mice

Academic Article
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Overview

authors

  • Kim, H. S.
  • Rhee, G. S.
  • Jung, J. Y.
  • Lee, Jiing-Dwan
  • Jang, Choon-Gon
  • Park, W. K.

publication date

  • March 1996

journal

  • Life Sciences  Journal

abstract

  • The N-methyl-D-aspartate (NMDA) subtype of glutamate receptors is an important mediator of several forms of neural and behavioral plasticity. In the present study, we examined the potential role of NMDA receptors in the glutamatergic modulation of dopaminergic function at the postsynaptic dopamine receptor by determining the effects of NMDA antagonists on apomorphine-induced climbing behavior in mice. The noncompetitive NMDA receptor antagonists, MK-801, ketamine, dextrorphan, and dextromethorphan attenuated the apomorphine-induced climbing behavior at does well below those that produce untoward side effects. These results suggest that the NMDA receptors play important roles in the glutamatergic modulation of dopaminergic function at the postsynaptic dopamine receptors that mediate the apomorphine-induced climbing behavior in mice.

subject areas

  • Animals
  • Apomorphine
  • Behavior, Animal
  • Dextromethorphan
  • Dextrorphan
  • Dizocilpine Maleate
  • Dopamine Agents
  • Ketamine
  • Male
  • Mice
  • Mice, Inbred ICR
  • Receptors, N-Methyl-D-Aspartate
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Research

keywords

  • MK-801
  • apomorphine
  • climbing behavior
  • dextromethorphan
  • dextrorphan
  • ketamine
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Identity

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(96)00109-9

PubMed ID

  • 8622565
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Additional Document Info

start page

  • 1397

end page

  • 1402

volume

  • 58

issue

  • 17

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