recent publications

• academic article

  • Xiong, W., Wagner, T., Yan, L., Grillet, N., Muller, U. Using injectoporation to deliver genes to mechanosensory hair cells Nature Protocols  2014 9:2438-2449  DOI:10.1038/nprot.2014.168  PMID:25232939  PMCID:PMC4241755
  • Mendus, D., Sundaresan, S., Grillet, N., Wangsawihardja, F., Leu, R., Muller, U., Jones, S. M., Mustapha, M. Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear European Journal of Neuroscience  2014 39:1256-1267  DOI:10.1111/ejn.12486  PMID:24460873  PMCID:PMC4132060
  • Wu, Z., Grillet, N., Yan, L., Xiong, W., Harkins-Perry, S., Muller, U. TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells Neuron  2014 84:954-967  DOI:10.1016/j.neuron.2014.10.041  PMID:25467981  PMCID:PMC4258123
  • Xiong, W., Grillet, N., Elledge, H. M., Wagner, T. F. J., Johnson, K. R., Kazmierczak, P., Muller, U. TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells Cell  2012 151:1283-1295  DOI:10.1016/j.cell.2012.10.041  PMID:23217710  PMCID:PMC3522178
  • Webb, S. W., Grillet, N., Andrade, L. R., Xiong, W., Swarthout, L., Della Santina, C. C., Kachar, B., Muller, U. Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain Development  2011 138:1607-1617  DOI:10.1242/dev.060061  PMID:21427143  PMCID:PMC3062428
  • Borck, G., Rehman, A. U., Lee, K., Pogoda, H. M., Kakar, N., von Ameln, S., Grillet, N., Hildebrand, M. S., Ahmed, Z. M., Nurnberg, G., Ansar, M., Basit, S., et al. Loss-of-function mutations of ildr1 cause autosomal-recessive hearing impairment dfnb42 American Journal of Human Genetics  2011 88:127-137  DOI:10.1016/j.ajhg.2010.12.011  PMID:21255762  PMCID:PMC3035704
  • Grillet, N., Schwander, M., Hildebrand, M. S., Sczaniecka, A., Kolatkar, A., Velasco, J., Webster, J. A., Kahrizi, K., Najmabadi, H., Kimberling, W. J., Stephan, D., Bahlo, M., et al. Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans American Journal of Human Genetics  2009 85:328-337  DOI:10.1016/j.ajhg.2009.07.017  PMID:19732867  PMCID:PMC2771534
  • Grillet, N., Kazmierczak, P., Xiong, W., Schwander, M., Reynolds, A., Sakaguchi, H., Tokita, J., Kachar, B., Muller, U. The mechanotransduction machinery of hair cells Science Signaling  2009 2:pt5  DOI:10.1126/scisignal.285pt5  PMID:19706872
  • Grillet, N., Xiong, W., Reynolds, A., Kazmierczak, P., Sato, T., Lillo, C., Dumont, R. A., Hintermann, E., Sczaniecka, A., Schwander, M., Williams, D., Kachar, B., et al. Harmonin mutations cause mechanotransduction defects in cochlear hair cells Neuron  2009 62:375-387  DOI:10.1016/j.neuron.2009.04.006  PMID:19447093  PMCID:PMC2691393
  • Schwander, M., Sczaniecka, A., Grillet, N., Bailey, J. S., Avenarius, M., Najmabadi, H., Steffy, B. M., Federe, G. C., Lagler, E. A., Banan, R., Hice, R., Grabowski-Boase, L., et al. A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function Journal of Neuroscience  2007 27:2163-2175  DOI:10.1523/jneurosci.4975-06.2007  PMID:17329413
  • Herr, D. R., Grillet, N., Schwander, M., Rivera, R., Muller, U., Chun, J. Sphingosine 1-phosphate S1P signaling is required for maintenance of hair cells mainly via activation of S1P2 Journal of Neuroscience  2007 27:1474-1478  DOI:10.1523/jneurosci.4245-06.2007  PMID:17287522
  • Grillet, N., Pattyn, A., Contet, C., Kieffer, B. L., Goridis, C., Brunet, J. F. Generation and characterization of Rgs4 mutant mice Molecular and Cellular Biology  2005 25:4221-4228  DOI:10.1128/mcb.25.10.4221-4228.2005  PMID:15870291  PMCID:PMC1087729