Organocatalytic enantioselective synthesis of metabotropic glutamate receptor ligands

Academic Article
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publication date

  • September 2005

abstract

  • (R)-Proline catalyzes the amination reaction of functionalized indane carboxaldehydes and allows for the efficient enantioselective synthesis (>99% ee) of the metabotropic glutamate receptor ligands (S)-AIDA and (S)-APICA. [reaction: see text]