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Organocatalytic enantioselective synthesis of metabotropic glutamate receptor ligands

Academic Article
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Overview

authors

  • Suri, J. T.
  • Steiner, D. D.
  • Barbas III, Carlos

publication date

  • September 2005

journal

  • Organic Letters  Journal

abstract

  • (R)-Proline catalyzes the amination reaction of functionalized indane carboxaldehydes and allows for the efficient enantioselective synthesis (>99% ee) of the metabotropic glutamate receptor ligands (S)-AIDA and (S)-APICA. [reaction: see text]

subject areas

  • Aldehydes
  • Amination
  • Catalysis
  • Excitatory Amino Acid Agonists
  • Indans
  • Ligands
  • Molecular Structure
  • Proline
  • Receptors, Metabotropic Glutamate
  • Stereoisomerism
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Identity

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol0512942

PubMed ID

  • 16119923
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Additional Document Info

start page

  • 3885

end page

  • 3888

volume

  • 7

issue

  • 18

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