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Effect of nociceptin/orphanin FQ on the rewarding properties of morphine

Academic Article
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Overview

authors

  • Ciccocioppo, R.
  • Angeletti, S.
  • Sanna, Pietro
  • Weiss, Friedbert
  • Massi, M.

publication date

  • September 2000

journal

  • European Journal of Pharmacology  Journal

abstract

  • The present study investigated the effect of nociceptin/orphanin FQ, the endogenous ligand of the opioid receptor-like 1 (ORL1) receptor, on the rewarding properties of morphine in the place conditioning paradigm. Intracerebroventricular (i.c.v.) injections of nociceptin/orphanin FQ, 500 or 1000 (but not 250) ng/rat, abolished conditioned place preference induced by subcutaneous (s.c.) injections of morphine (3 mg/kg). These doses of nociceptin/orphanin FQ induced neither place aversion nor preference per se. The same doses did not modify the rat performance in the Morris water test, suggesting that they do not disrupt spatial learning and memory. Moreover, these doses of nociceptin/orphanin FQ did not modify the development of morphine-induced locomotor sensitization, suggesting that they do not interfere with sensitization processes to morphine. The present results confirm and extend previous reports that nociceptin/orphanin FQ is able to abolish morphine-induced conditioned place preference, and raise interest for the possible role of nociceptin/orphanin FQ and ORL1 receptors in the control of opiate abuse.

subject areas

  • Animals
  • Conditioning (Psychology)
  • Drug Interactions
  • Male
  • Morphine
  • Morphine Dependence
  • Motor Activity
  • Opioid Peptides
  • Rats
  • Rats, Wistar
  • Reward
  • Swimming
  • Vasodilator Agents
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Research

keywords

  • ORL1 receptor
  • conditioned place preference
  • locomotor sensitization
  • morphine
  • nociceptin
  • orphanin FQ
  • spatial learning
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Identity

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/s0014-2999(00)00590-2

PubMed ID

  • 10980274
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Additional Document Info

start page

  • 153

end page

  • 159

volume

  • 404

issue

  • 1-2

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