recent publications

• academic article

  • Petasis, N. A., Akritopoulou-Zanze, I., Fokin, V. V., Bernasconi, G., Keledjian, R., Yang, R., Uddin, J., Nagulapalli, K. C., Serhan, C. N. Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins Prostaglandins Leukotrienes and Essential Fatty Acids  2005 73:301-321  DOI:10.1016/j.plefa.2005.05.020  PMID:16098719
  • Gewirtz, A. T., Fokin, V. V., Petasis, N. A., Serhan, C. N., Madara, J. L. LXA(4), aspirin-triggered 15-epi-LXA(4), and their analogs selectively downregulate PMN azurophilic degranulation American Journal of Physiology-Cell Physiology  1999 276:C988-C994  PMID:10199831
  • Levy, B. D., Fokin, V. V., Clark, J. M., Wakelam, M. J. O., Petasis, N. A., Serhan, C. N. Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A(4) FASEB Journal  1999 13:903-911  PMID:10224233
  • Maddox, J. F., Colgan, S. P., Clish, C. B., Petasis, N. A., Fokin, V. V., Serhan, C. N. Lipoxin B(4) regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B(4) analogs with increased biologic activity FASEB Journal  1998 12:487-494  PMID:9535221
  • Maddox, J. F., Hachicha, M., Takano, T., Petasis, N. A., Fokin, V. V., Serhan, C. N. Lipoxin A(4) stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A(4) receptor Journal of Biological Chemistry  1997 272:6972-6978  PMID:9054386
  • Nicolaou, K. C., Ramphal, J. Y., Petasis, N. A., Serhan, C. N. Lipoxins and related eicosanoids - biosynthesis, biological properties, and chemical synthesis Angewandte Chemie-International Edition  1991 30:1100-1116  DOI:10.1002/anie.199111001
  • Luscinskas, F. W., Nicolaou, K. C., Webber, S. E., Veale, C. A., Gimbrone, M. A., Serhan, C. N. Ca-2+ mobilization with leukotriene-a4 and epoxytetraenes in human-neutrophils Biochemical Pharmacology  1990 39:355-365  DOI:10.1016/0006-2952(90)90035-j  PMID:2154229
  • Fiore, S., Nicolaou, K. C., Caulfield, T., Kataoka, H., Serhan, C. N. Evaluation of synthetic sphingosine, lysosphingolipids and glycosphingolipids as inhibitors of functional-responses of human neutrophils Biochemical Journal  1990 266:25-31  PMID:2155608  PMCID:PMC1131091
  • Lee, T. H., Crea, A. E. G., Gant, V., Spur, B. W., Marron, B. E., Nicolaou, K. C., Reardon, E., Brezinski, M., Serhan, C. N. Identification of lipoxin-a4 and its relationship to the sulfidopeptide leukotriene-c4, leukotriene-d4, and leukotriene-e4 in the bronchoalveolar lavage fluids obtained from patients with selected pulmonary-diseases American Review of Respiratory Disease  1990 141:1453-1458  PMID:2161628
  • Nicolaou, K. C., Marron, B. E., Veale, C. A., Webber, S. E., Dahlen, S. E., Samuelsson, B., Serhan, C. N. Identification of a novel 7-cis-11-trans-lipoxin a4 generated by human-neutrophils - total synthesis, spasmogenic activities and comparison with other geometric isomers of lipoxins a4 and b4 Biochimica et Biophysica Acta  1989 1003:44-53  DOI:10.1016/0005-2760(89)90096-9  PMID:2713393
  • Brezinski, M. E., Gimbrone, M. A., Nicolaou, K. C., Serhan, C. N. Lipoxins stimulate prostacyclin generation by human-endothelial cells FEBS Letters  1989 245:167-172  DOI:10.1016/0014-5793(89)80214-5  PMID:2494071
  • Dahlen, S. E., Veale, C. A., Webber, S. E., Marron, B. E., Nicolaou, K. C., Serhan, C. N. Pharmacodynamics of lipoxin-a4 in airway smooth-muscle Agents and Actions  1989 26:93-95  DOI:10.1007/bf02126570  PMID:2711954
  • Marron, B. E., Spanevello, R. A., Elisseou, M. E., Serhan, C. N., Nicolaou, K. C. Synthesis of 19,19,20,20,20-pentadeuteriolipoxin-a4 methyl-ester and 19,19,20,20,20-pentadeuterioarachidonic acid - agents for use in the quantitative detection of naturally-occurring eicosanoids Journal of Organic Chemistry  1989 54:5522-5527  DOI:10.1021/jo00284a025
  • Nicolaou, K. C., Marron, B. E., Veale, C. A., Webber, S. E., Serhan, C. N. Total synthesis of novel geometric isomers of lipoxin-a4 and lipoxin-b4 Journal of Organic Chemistry  1989 54:5527-5535  DOI:10.1021/jo00284a026
  • Ramstedt, U., Serhan, C. N., Nicolaou, K. C., Webber, S. E., Wigzell, H., Samuelsson, B. Lipoxin a-induced inhibition of human natural-killer-cell cytotoxicity - studies on stereospecificity of inhibition and mode of action Journal of Immunology  1987 138:266-270  PMID:3782800
  • Badr, K. F., Serhan, C. N., Nicolaou, K. C., Samuelsson, B. The action of lipoxin-a on glomerular microcirculatory dynamics in the rat Biochemical and Biophysical Research Communications  1987 145:408-414  DOI:10.1016/0006-291x(87)91337-4  PMID:3593345
  • Palmblad, J., Gyllenhammar, H., Ringertz, B., Serhan, C. N., Samuelsson, B., Nicolaou, K. C. The effect of lipoxin-a and lipoxin-b on functional-responses of human-granulocytes Biochemical and Biophysical Research Communications  1987 145:168-175  DOI:10.1016/0006-291x(87)91302-7  PMID:3593338
  • Puustinen, T., Webber, S. E., Nicolaou, K. C., Haeggstrom, J., Serhan, C. N., Samuelsson, B. Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human-leukocytes - conversion into lipoxin-a by cytosolic epoxide hydrolase FEBS Letters  1986 207:127-132  DOI:10.1016/0014-5793(86)80025-4  PMID:3770188
  • Serhan, C. N., Nicolaou, K. C., Webber, S. E., Veale, C. A., Dahlen, S. E., Puustinen, T. J., Samuelsson, B. Lipoxin-a - stereochemistry and biosynthesis Journal of Biological Chemistry  1986 261:6340-6345