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Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila

Academic Article
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Overview

authors

  • Franc, Nathalie
  • Heitzler, P.
  • Ezekowitz, R. A. B.
  • White, K.

publication date

  • June 1999

journal

  • Science  Journal

abstract

  • Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila.

subject areas

  • Animals
  • Antigens, CD36
  • Apoptosis
  • Carrier Proteins
  • Drosophila
  • Drosophila Proteins
  • Embryo, Nonmammalian
  • Escherichia coli
  • Gene Deletion
  • Gene Expression Regulation, Developmental
  • Genes, Insect
  • Ion Pumps
  • Macrophages
  • Membrane Proteins
  • Phagocytosis
  • Phenotype
  • Receptors, Immunologic
  • Receptors, Scavenger
  • Staphylococcus aureus
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.284.5422.1991

PubMed ID

  • 10373118
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Additional Document Info

start page

  • 1991

end page

  • 1994

volume

  • 284

issue

  • 5422

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