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V-beta repertoire in rats and implications for endogenous superantigens

Academic Article
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Overview

authors

  • Smith, L. R.
  • Kono, Dwight
  • Kammuller, M. E.
  • Balderas, R. S.
  • Theofilopoulos, Argyrios

publication date

  • March 1992

journal

  • European Journal of Immunology  Journal

abstract

  • Endogenous superantigens of mice, encoded by mammary tumor virus proviral integrants, induce intrathymic deletion of entire T cell populations that express specific V beta gene products, a phenomenon proposed to be important in self-tolerance and prevention of toxic responses to exogenous microbial superantigens. Evidence for the presence of V beta selecting/deleting endogenous superantigens in other species is lacking. We report here that rats do not exhibit endogenous superantigen-induced V beta clonal deletions despite their strong response to bacterial superantigens. These findings indicate that endogenous superantigens are not obligatory in V beta repertoire shaping.

subject areas

  • Animals
  • Antigens, Viral
  • Bacterial Toxins
  • Mammary Tumor Virus, Mouse
  • Mice
  • Rats
  • Rats, Inbred Strains
  • Receptors, Antigen, T-Cell, alpha-beta
  • Species Specificity
  • Transcription, Genetic
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Identity

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/eji.1830220305

PubMed ID

  • 1312471
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Additional Document Info

start page

  • 641

end page

  • 645

volume

  • 22

issue

  • 3

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