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Self-assembly dynamics of a cylindrical capsule monitored by fluorescence resonance energy transfer

Academic Article
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Overview

related to degree

  • Dale, Trevor, Ph.D. in Chemistry, Scripps Research 2003 - 2008

authors

  • Barrett, E. S.
  • Dale, Trevor
  • Rebek Jr., Julius

publication date

  • July 2007

journal

  • Journal of the American Chemical Society  Journal

abstract

  • The constituent cavitands of a cylindrical capsule were labeled with donor and acceptor fluorophores, and fluorescence resonance energy transfer (FRET) was employed as a tool to study the dynamics of self-assembly. When donor and acceptor dyes are present in the same capsular assembly, they are brought within 25 A of each other, a distance suitable for efficient energy transfer to occur between them. This allowed for the study of interacting species at nanomolar concentrations providing information unattainable from NMR experiments. The kinetic stability of the capsule in the presence of various guest molecules was investigated which revealed a range of more than 4 orders of magnitude in the rates of cylindrical capsule exchange. While the thermodynamic stability of the capsule generally dictates the self-assembly dynamics, it was discovered that longer rigid guests can impart a significant kinetic barrier to monomer exchange.

subject areas

  • Capsules
  • Fluorescence Resonance Energy Transfer
  • Fluorescent Dyes
  • Kinetics
  • Macromolecular Substances
  • Molecular Probe Techniques
  • Thermodynamics
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Identity

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja071774j

PubMed ID

  • 17592844
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Additional Document Info

start page

  • 8818

end page

  • 8824

volume

  • 129

issue

  • 28

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