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Lymphoid reservoirs of antigen-specific memory t helper cells

Academic Article
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Overview

authors

  • Fazilleau, N.
  • Eisenbraun, M. D.
  • Malherbe, L.
  • Ebright, J. N.
  • Pogue-Caley, R. R.
  • McHeyzer-Williams, L. J.
  • McHeyzer-Williams, Michael G.

publication date

  • July 2007

journal

  • Nature Immunology  Journal

abstract

  • How vaccines control the development of antigen-specific effector and memory T helper cells is central to protective immunity but remains poorly understood. Here we found that protein vaccination selected high-affinity, CXCR5+ICOS(hi) follicular B-helper T cells (T(FH) cells) that developed in draining lymphoid tissue to regulate B cell responses. In the memory phase, reservoirs of antigen-specific CXCR5+ICOS(lo) T(FH) cells persisted with less effector activity but accelerated antigen-recall ability. This new compartment of memory T(FH) cells was retained in draining lymphoid sites with antigen-specific memory B cells, persistent complexes of peptide and major histocompatibility complex class II and continued expression of CD69. Thus, protein vaccination promotes B cell immunity by selecting high-affinity effector T(FH) cells and creating lymphoid reservoirs of antigen-specific memory T(FH) cells in vivo.

subject areas

  • Animals
  • Cell Adhesion
  • Cells, Cultured
  • Clone Cells
  • Columbidae
  • Cytochromes c
  • Epitopes, T-Lymphocyte
  • Immunologic Memory
  • Lymph Nodes
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • T-Lymphocyte Subsets
  • T-Lymphocytes, Helper-Inducer
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Identity

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni1472

PubMed ID

  • 17529982
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Additional Document Info

start page

  • 753

end page

  • 761

volume

  • 8

issue

  • 7

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