Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Age-related differences in the blood alcohol levels of wistar rats

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Walker, B. M.
  • Ehlers, Cindy

publication date

  • 2009

journal

  • Pharmacology, Biochemistry and Behavior  Journal

abstract

  • Knowledge of blood alcohol levels (BALs) that are achieved following ethanol administration is critical for contemporary efforts to develop animal models of alcoholism. Adolescent and adult male Wistar rats were administered varying doses of ethanol (0.75, 1.5 and 3.0 g/kg) via gavage or intraperitoneal injection and BALs were measured over a two hour period. The results showed that adolescent animals had lower BALs across all time points in comparison to adults following administration of 0.75 g/kg ethanol and that 1 h after administration of 1.5 g/kg ethanol, adolescent animals showed an enhanced rate of elimination. The highest dose of ethanol (3.0 g/kg) produced comparable BALs for both adolescents and adults during the two-hour sampling period; however, the BALs for both ages were lower following administration of ethanol by gavage at this dose. Furthermore, an order effects analysis highlights that depending on the route of administration, initial dose size can influence the BALs produced by lower doses of ethanol. The current data identify the importance of measuring the level of alcohol in the blood to confirm that target BALs are achieved for adolescents and equivalent BALs are being reached for both adolescent and adult animals when such comparisons are made.

subject areas

  • Aging
  • Animals
  • Central Nervous System Depressants
  • Data Interpretation, Statistical
  • Ethanol
  • Injections, Intraperitoneal
  • Intubation, Gastrointestinal
  • Male
  • Rats
  • Rats, Wistar
scroll to property group menus

Research

keywords

  • Adolescent
  • Adult
  • Blood alcohol level
  • Ethanol
  • Gavage
  • Intraperitoneal
  • Pharmacokinetics
scroll to property group menus

Identity

PubMed Central ID

  • PMC2766013

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/j.pbb.2008.09.017

PubMed ID

  • 18940195
scroll to property group menus

Additional Document Info

start page

  • 560

end page

  • 565

volume

  • 91

issue

  • 4

©2019 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support