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Synthesis on soluble polymers: New reactions and the construction of small molecules

Academic Article
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Overview

authors

  • Gravert, D. J.
  • Janda, Kim

publication date

  • June 1997

journal

  • Current Opinion in Chemical Biology  Journal

abstract

  • To avoid the heterogeneous reaction conditions of solid-phase chemistry, liquid-phase synthesis provides homogeneity through the use of soluble polymer supports that can be selectively precipitated and filtered to achieve product purification. Peptides, oligonucleotides, and oligosaccharides have been synthesized by this method. Furthermore, combinatorial libraries of small molecules have been produced by liquid-phase synthesis to aid in the search for new pharmaceutical agents including compounds active against HIV. Soluble polymeric reagents have also been developed for greater ease and efficiency in organic synthesis.

subject areas

  • Indicators and Reagents
  • Oligonucleotides
  • Oligosaccharides
  • Peptide Library
  • Polymers
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Identity

International Standard Serial Number (ISSN)

  • 1367-5931

Digital Object Identifier (DOI)

  • 10.1016/s1367-5931(97)80116-0

PubMed ID

  • 9667833
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Additional Document Info

start page

  • 107

end page

  • 113

volume

  • 1

issue

  • 1

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