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Cd14, a receptor for complexes of lipopolysaccharide (lps) and lps binding-protein

Academic Article
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Overview

authors

  • Wright, S. D.
  • Ramos, R. A.
  • Tobias, Peter
  • Ulevitch, Richard
  • Mathison, J. C.

publication date

  • September 1990

journal

  • Science  Journal

abstract

  • Leukocytes respond to lipopolysaccharide (LPS) at nanogram per milliliter concentrations with secretion of cytokines such as tumor necrosis factor-alpha (TNF-alpha). Excess secretion of TNF-alpha causes endotoxic shock, an often fatal complication of infection. LPS in the bloodstream rapidly binds to the serum protein, lipopolysaccharide binding protein (LBP), and cellular responses to physiological levels of LPS are dependent on LBP. CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF-alpha by whole blood incubated with LPS. Thus, LPS may induce responses by interacting with a soluble binding protein in serum that then binds the cell surface protein CD14.

subject areas

  • Acute-Phase Proteins
  • Animals
  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, CD14
  • Antigens, CD18
  • Antigens, Differentiation, Myelomonocytic
  • Carrier Proteins
  • Erythrocytes
  • Leukocytes
  • Lipopolysaccharides
  • Macrophages
  • Membrane Glycoproteins
  • Receptors, Leukocyte-Adhesion
  • Sheep
  • Tumor Necrosis Factor-alpha
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1698311

PubMed ID

  • 1698311
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Additional Document Info

start page

  • 1431

end page

  • 1433

volume

  • 249

issue

  • 4975

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