Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Modulation of early inflammatory reactions to promote engraftment and function of transplanted pancreatic islets in autoimmune diabetes

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Piemonti, L.
  • Guidotti, Luca
  • Battaglia, M.

publication date

  • 2010

journal

  • Advances in Experimental Medicine and Biology  Journal

abstract

  • We acknowledge that successful long-term islet survival in the liver and immune tolerance to intrahepatic islet antigens are highly dependent upon the initial inflammatory and priming events that occur at this site. Thromboembolic and necroinflammatory events occurring in the liver early after portal vein islet transplantation are thought to reduce the total islet mass by up to 75%. The magnitude of such loss represents a major factor necessitating the extremely large number of islets needed to achieve normoglycemia. A better understanding and control of these events - including their likely support to effector immune responses - are required if we are to develop ways to prevent them, improve intrahepatic islet engraftment, and achieve long-term tolerance.

subject areas

  • Animals
  • Biocompatible Materials
  • Cytoprotection
  • Diabetes Mellitus, Type 1
  • Graft Survival
  • Humans
  • Immune Tolerance
  • Inflammation
  • Islets of Langerhans
  • Islets of Langerhans Transplantation
  • Liver
  • Mice
  • Mice, Inbred BALB C
  • Portal Vein
scroll to property group menus

Research

keywords

  • Instant blood-mediated inflammatory reaction
  • Pancreatic islet transplantation
  • Type 1 diabetes
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0065-2598 978-90-481-3270-6

Digital Object Identifier (DOI)

  • 10.1007/978-90-481-3271-3_32

PubMed ID

  • 20217522
scroll to property group menus

Additional Document Info

start page

  • 725

end page

  • 747

volume

  • 654

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support