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Malfolded protein structure and proteostasis in lung diseases

Academic Article
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Overview

authors

  • Balch, William E.
  • Sznajder, J. I.
  • Budinger, S.
  • Finley, D.
  • Laposky, A. D.
  • Cuervo, A. M.
  • Benjamin, I. J.
  • Barreiro, E.
  • Morimoto, R. I.
  • Postow, L.
  • Weissman, A. M.
  • Gail, D.
  • Banks-Schlegel, S.
  • Croxton, T.
  • Gan, W.

publication date

  • January 2014

journal

  • American Journal of Respiratory and Critical Care Medicine  Journal

abstract

  • Recent discoveries indicate that disorders of protein folding and degradation play a particularly important role in the development of lung diseases and their associated complications. The overarching purpose of the National Heart, Lung, and Blood Institute workshop on "Malformed Protein Structure and Proteostasis in Lung Diseases" was to identify mechanistic and clinical research opportunities indicated by these recent discoveries in proteostasis science that will advance our molecular understanding of lung pathobiology and facilitate the development of new diagnostic and therapeutic strategies for the prevention and treatment of lung disease. The workshop's discussion focused on identifying gaps in scientific knowledge with respect to proteostasis and lung disease, discussing new research advances and opportunities in protein folding science, and highlighting novel technologies with potential therapeutic applications for diagnosis and treatment.

subject areas

  • Aging
  • Biomedical Research
  • Drug Discovery
  • Education
  • Humans
  • Lung Diseases
  • National Heart, Lung, and Blood Institute (U.S.)
  • Protein Folding
  • Proteostasis Deficiencies
  • United States
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Research

keywords

  • post-translational processing
  • protein misfolding
  • proteosome
  • pulmonary health
  • ubiquitination
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Identity

PubMed Central ID

  • PMC3919126

International Standard Serial Number (ISSN)

  • 1073-449X

Digital Object Identifier (DOI)

  • 10.1164/rccm.201306-1164WS

PubMed ID

  • 24033344
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Additional Document Info

start page

  • 96

end page

  • 103

volume

  • 189

issue

  • 1

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