B cells discriminate the rules of engagement

Academic Article

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Overview

authors

• McHeyzer-Williams, Michael G.
• McHeyzer-Williams, L. J.
• Malherbe, L.

publication date

• February 2006

journal

• Immunity  Journal

abstract

• How B cells discriminate antigen-receptor-mediated signals in development and navigate critical checkpoints in adaptive immune responses remains poorly resolved. In this issue of Immunity, conditionally ablate the main regulatory subunit of the calcineurin phosphatase complex in B cells to reveal both positive and negative influences on the development of antibody responses and B cell memory.

subject areas

• Animals
• Antigens, T-Independent
• B-Lymphocytes
• Calcineurin
• Calcium
• Germinal Center
• Mice
• Models, Biological
• Phosphoric Monoester Hydrolases
• Signal Transduction
• T-Lymphocytes

Identity

International Standard Serial Number (ISSN)

• 1074-7613

Digital Object Identifier (DOI)

• 10.1016/j.immuni.2006.01.009

PubMed ID

• 16473823

Additional Document Info

start page

• 125

end page

• 127

volume

• 24

issue

• 2