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Nuclear receptors, metabolism, and the circadian clock

Academic Article
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Overview

authors

  • Yang, X.
  • Lamia, Katja
  • Evans, R. M.

publication date

  • 2007

journal

  • Cold Spring Harbor Symposia on Quantitative Biology  Journal

abstract

  • As ligand-dependent transcription factors, the nuclear receptor superfamily governs a remarkable array of rhythmic physiologic processes such as metabolism and reproduction. To provide a "molecular blueprint" for nuclear receptor function in circadian biology, we established a diurnal expression profile of all mouse nuclear receptors in critical metabolic tissues. Our finding of broad expression and tissue-specific oscillation of nuclear receptors along with their key target genes suggests that diurnal nuclear receptor expression may contribute to established rhythms in metabolic physiology and that nuclear receptors may be involved in coupling peripheral circadian clocks to divergent metabolic outputs. Conversely, nuclear receptors may serve peripheral clock input pathways, integrating signals from the light-sensing central clock in the suprachiasmatic nucleus and other environmental cues, such as nutrients and xenobiotics. Interplay between the core circadian clock and nuclear receptors may define a large-scale signaling network that links biological timing to metabolic physiology.

subject areas

  • Animals
  • Circadian Rhythm
  • Glucocorticoids
  • Ligands
  • Models, Biological
  • Peroxisome Proliferator-Activated Receptors
  • Receptors, Cytoplasmic and Nuclear
  • Signal Transduction
  • Suprachiasmatic Nucleus
  • Thyroid Hormones
  • Transcription Factors
  • Tretinoin
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Identity

International Standard Serial Number (ISSN)

  • 0091-7451 (Print) 0091-7451 (Linking)

Digital Object Identifier (DOI)

  • 10.1101/sqb.2007.72.058

PubMed ID

  • 18419296
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Additional Document Info

start page

  • 387

end page

  • 394

volume

  • 72

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