Role of N-acyl amino acid ligands in Pd(II)-catalyzed remote C-H activation of tethered arenes

Academic Article
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publication date

  • 2014

abstract

  • A combined experimental/computational study on the amino acid ligand-assisted Pd-catalyzed C-H bond activation reveals a mechanism in which the amino acid acts as both a dianionic bidentate ligand and a proton acceptor. This new model explains the effects of amino acids on reactivity and selectivity and unveils the dual roles of amino acids: stabilizing monomeric Pd complexes and serving as the internal base for proton abstraction.