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Hypoxanthine and oxygen induced lung injury: a possible basic mechanism of tissue damage?

Academic Article
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Overview

authors

  • Saugstad, O. D.
  • Hallman, M.
  • Abraham, J. L.
  • Epstein, B.
  • Cochrane, Charles
  • Gluck, L.

publication date

  • 1984

journal

  • Pediatric Research  Journal

abstract

  • Lung injury was induced in young rats by a continuous infusion of hypoxanthine intravenously and breathing 100% oxygen for 48 h (group 1). Control animals were rats infused glucose and breathing 100% oxygen (group 2), rats infused hypoxanthine in room air (group 3), and untreated rats (group 4). In group 1 rats interstitial and alveolar edema was found with a tendency toward marked margination of polymorphonuclear neutrophils in small vessels (P less than 0.025 compared with group 2). The main elastase inhibitor alpha 1-antitrypsin (alpha-1-PI) was significantly elevated in group 1; 2-, 3- and 5-fold, respectively, when compared with groups 2, 3, and 4. The surfactant phospholipids from alveolar lavage were normal in all groups. The protein-rich fraction of the lavage fluid from group 1 rats inactivated, however, the surface properties of lung surfactant. Minimum surface tension in group 1 rats was 14.5 dyn/cm compared with 7.0 dyn/cm in group 2, 2.9 dyn/cm in group 3 and 3.5 dyn/cm in group 4 (P less than 0.05, group 1 and 2 versus 4). We conclude that the combination of hypoxanthine and high levels of oxygen causes lung injury, possibly via free oxygen radicals. We discuss the possibility that these findings demonstrate a basic pathogenetic mechanism for the hypoxic-hyperoxic insult and can contribute to the understanding of pathogenesis of a variety of diseases both in pediatrics and adult medicine.

subject areas

  • Animals
  • Female
  • Free Radicals
  • Hypoxanthine
  • Hypoxanthines
  • Lung
  • Lung Diseases
  • Neutrophils
  • Oxygen
  • Pancreatic Elastase
  • Phospholipids
  • Pulmonary Surfactants
  • Rats
  • Rats, Inbred Strains
  • alpha 1-Antitrypsin
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Identity

International Standard Serial Number (ISSN)

  • 0031-3998

Digital Object Identifier (DOI)

  • 10.1203/00006450-198406000-00002

PubMed ID

  • 6610852
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Additional Document Info

start page

  • 501

end page

  • 504

volume

  • 18

issue

  • 6

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