Palladium-catalysed biscyclisation of allenic bromoalkenes through a zipper-mode cascade

Academic Article
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publication date

  • 2008

abstract

  • Treatment of allenic bromoalkenes bearing a nucleophilic moiety with a catalytic amount of palladium(0) in the presence of TBAF or Cs(2)CO(3) in MeCN affords bicyclic heterocycles in good to high yields, through zipper-mode cascade cyclisation.