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Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation

Academic Article
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Overview

authors

  • Toda, N.
  • Asano, S.
  • Barbas III, Carlos

publication date

  • November 2013

journal

  • Angewandte Chemie-International Edition  Journal

subject areas

  • Click Chemistry
  • Cysteine
  • Humans
  • Maleimides
  • Models, Molecular
  • Oxadiazoles
  • Plasma
  • Protein Stability
  • Proteins
  • Sulfhydryl Compounds
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Research

keywords

  • chemoselectivity
  • cysteine
  • drug conjugates
  • phenyloxadiazole
  • protein conjugation
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Identity

PubMed Central ID

  • PMC3865870

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/anie.201306241

PubMed ID

  • 24123851
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Additional Document Info

start page

  • 12592

end page

  • 12596

volume

  • 52

issue

  • 48

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