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Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity

Academic Article
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Overview

authors

  • Edwards, S.
  • Baynes, B. B.
  • Carmichael, C. Y.
  • Zamora-Martinez, E. R.
  • Barrus, M.
  • Koob, George
  • Gilpin, N. W.

publication date

  • August 2013

journal

  • Translational Psychiatry  Journal

abstract

  • Post-traumatic stress disorder (PTSD) and alcoholism are highly comorbid in humans and have partially overlapping symptomatic profiles. The aim of these studies was to examine the effects of traumatic stress (and stress reactivity) on alcohol-related behaviors and neuronal activation patterns. Male Wistar rats were trained to respond for alcohol, were exposed to predator odor (bobcat urine) paired with context and were tested for short- and long-term avoidance of the predator odor-paired context, alcohol self-administration and compulsivity of alcohol responding. Rats were re-exposed to the odor-paired context for western blot analysis of ERK phosphorylation in subregions of the medial prefrontal cortex (mPFC) and the amygdala. Rats that avoided the predator-paired chamber (Avoiders) exhibited persistent avoidance up to 6 weeks post conditioning. Avoiders exhibited increases in operant alcohol responding over weeks, as well as more compulsive-like responding for alcohol adulterated with quinine. Following re-exposure to the predator odor-paired context, Avoiders and Non-Avoiders exhibited unique patterns of neuronal activation in subregions of the mPFC and the amygdala, which were correlated with changes in avoidance and alcohol drinking. Furthermore, activity of upstream regions was differentially predictive of downstream regional activity in the Avoiders versus Non-Avoiders. An animal model for assessing the effect of traumatic stress on alcohol drinking reveals individual differences in neuronal activation patterns associated with re-exposure to traumatic stress-related stimuli, and may provide insight into the neural mechanisms underlying excessive alcohol consumption in humans with PTSD.

subject areas

  • Alcohol Drinking
  • Alcoholism
  • Amygdala
  • Animals
  • Avoidance Learning
  • Compulsive Behavior
  • Conditioning, Classical
  • Conditioning, Operant
  • Disease Models, Animal
  • Extracellular Signal-Regulated MAP Kinases
  • MAP Kinase Signaling System
  • Male
  • Phosphorylation
  • Prefrontal Cortex
  • Rats
  • Rats, Wistar
  • Stress Disorders, Post-Traumatic
  • Stress, Psychological
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Research

keywords

  • PTSD
  • alcohol abuse
  • avoidance
  • escalation
  • individual differences
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Identity

PubMed Central ID

  • PMC3756295

International Standard Serial Number (ISSN)

  • 2158-3188

Digital Object Identifier (DOI)

  • 10.1038/tp.2013.70

PubMed ID

  • 23982628
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Additional Document Info

start page

  • e296

volume

  • 3

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