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Cyclic AMP imaging sheds light on PDF signaling in circadian clock neurons

Academic Article
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Overview

authors

  • Tomchik, Seth
  • Davis, Ronald

publication date

  • April 2008

journal

  • Neuron  Journal

abstract

  • In Drosophila, the neuropeptide PDF is required for circadian rhythmicity, but it is unclear where PDF acts. In this issue of Neuron, Shafer et al. use a novel bioimaging methodology to demonstrate that PDF elevates cAMP in nearly all clock neurons. Thus, PDF apparently exerts more widespread effects on the circadian clock network than suggested by previous studies of PDF receptor expression.

subject areas

  • Animals
  • Circadian Rhythm
  • Cyclic AMP
  • Drosophila Proteins
  • Neurons
  • Neuropeptides
  • Signal Transduction
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Identity

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2008.04.008

PubMed ID

  • 18439399
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Additional Document Info

start page

  • 161

end page

  • 163

volume

  • 58

issue

  • 2

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