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Cross-talk between intraepithelial gamma delta T cells and epithelial cells

Academic Article
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Overview

authors

  • Witherden, D. A.
  • Havran, Wendy

publication date

  • July 2013

journal

  • Journal of Leukocyte Biology  Journal

abstract

  • Intraepithelial γδ T cells play pivotal roles in homeostasis, tissue repair, inflammation, and protection from malignancy. In some tissues, γδ T cells are the only resident T cell population, whereas in others, they coexist with αβ T cells and other lymphocyte populations. γδ T cell function in the epithelium requires constant communication between cells in the form of cell-to-cell contacts and cell-to-matrix interactions. These interactions coordinate with the timely production of specific cytokines, chemokines, growth factors, and glycosaminoglycans, which have specialized effects on neighboring epithelial cells. Antigens that activate these T cells are not well-defined, and they do not express classic costimulatory or coreceptor molecules. As such, an understanding of the mechanisms used by epithelial γδ T cells to maintain homeostasis and facilitate wound repair has necessitated the identification of novel molecular interactions between γδ T cells and their neighboring epithelial cells.

subject areas

  • Animals
  • Cell Communication
  • Epithelial Cells
  • Humans
  • Lymphocytes
  • Receptors, Antigen, T-Cell, gamma-delta
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Research

keywords

  • dendritic epidermal T cells
  • epithelium
  • lymphocytes
  • wound repair
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Identity

PubMed Central ID

  • PMC3685022

International Standard Serial Number (ISSN)

  • 1938-3673 (Electronic) 0741-5400 (Linking)

Digital Object Identifier (DOI)

  • 10.1189/jlb.0213101

PubMed ID

  • 23620015
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Additional Document Info

start page

  • 69

end page

  • 76

volume

  • 94

issue

  • 1

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