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An expanded genetic code in mammalian cells with a functional quadruplet codon

Academic Article
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Overview

authors

  • Niu, W.
  • Schultz, Peter
  • Guo, J. T.

publication date

  • July 2013

journal

  • ACS Chemical Biology  Journal

abstract

  • We have utilized in vitro evolution to identify tRNA variants with significantly enhanced activity for the incorporation of unnatural amino acids into proteins in response to a quadruplet codon in both bacterial and mammalian cells. This approach will facilitate the creation of an optimized and standardized system for the genetic incorporation of unnatural amino acids using quadruplet codons, which will allow the biosynthesis of biopolymers that contain multiple unnatural building blocks.

subject areas

  • Amino Acid Sequence
  • Animals
  • Codon
  • Escherichia
  • Evolution, Molecular
  • Fluorescence
  • Gene Library
  • Genetic Code
  • Genetic Variation
  • Humans
  • RNA, Transfer
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Identity

PubMed Central ID

  • PMC4501474

International Standard Serial Number (ISSN)

  • 1554-8929

Digital Object Identifier (DOI)

  • 10.1021/cb4001662

PubMed ID

  • 23662731
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Additional Document Info

start page

  • 1640

end page

  • 1645

volume

  • 8

issue

  • 7

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