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Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 hemagglutinin

Academic Article
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Overview

related to degree

  • Ekiert, Damian, Ph.D. in Chemical Biology, Scripps Research 2006 - 2011

authors

  • Dreyfus, C.
  • Ekiert, Damian
  • Wilson, Ian

publication date

  • June 2013

journal

  • Journal of Virology  Journal

abstract

  • We report the structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets an epitope on the HA stem similar to those targeted by the recently identified human broadly neutralizing antibodies. C179 also inhibits the low-pH conformational change of the HA but uses a different angle of approach and both heavy and light chains.

subject areas

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Cross Reactions
  • Crystallography, X-Ray
  • Epitopes
  • Hemagglutinin Glycoproteins, Influenza Virus
  • Humans
  • Influenza A Virus, H2N2 Subtype
  • Influenza A virus
  • Influenza, Human
  • Mice
  • Models, Molecular
  • Molecular Sequence Data
  • Neutralization Tests
  • Pandemics
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Identity

PubMed Central ID

  • PMC3676097

International Standard Serial Number (ISSN)

  • 1098-5514 (Electronic) 0022-538X (Linking)

Digital Object Identifier (DOI)

  • 10.1128/jvi.02975-12

PubMed ID

  • 23552413
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Additional Document Info

start page

  • 7149

end page

  • 7154

volume

  • 87

issue

  • 12

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