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SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity

Academic Article
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Overview

authors

  • Clement, J. P.
  • Ozkan, E. D.
  • Aceti, Massimiliano
  • Miller, Courtney
  • Rumbaugh, Gavin

publication date

  • June 2013

journal

  • Journal of Neuroscience  Journal

abstract

  • Critical periods of developmental plasticity contribute to the refinement of neural connections that broadly shape brain development. These windows of plasticity are thought to be important for the maturation of perception, language, and cognition. Synaptic properties in cortical regions that underlie critical periods influence the onset and duration of windows, although it remains unclear how mechanisms that shape synapse development alter critical-period properties. In this study, we demonstrate that inactivation of a single copy of syngap1, which causes a surprisingly common form of sporadic, non-syndromic intellectual disability with autism in humans, induced widespread early functional maturation of excitatory connections in the mouse neocortex. This accelerated functional maturation was observed across distinct areas and layers of neocortex and directly influenced the duration of a critical-period synaptic plasticity associated with experience-dependent refinement of cortical maps. These studies support the idea that genetic control over synapse maturation influences the duration of critical-period plasticity windows. These data also suggest that critical-period duration links synapse maturation rates to the development of intellectual ability.

subject areas

  • Animals
  • Brain
  • Brain Mapping
  • Cognition
  • Critical Period (Psychology)
  • Data Interpretation, Statistical
  • Electric Stimulation
  • Female
  • In Vitro Techniques
  • Long-Term Potentiation
  • Male
  • Mice
  • Neocortex
  • Neuronal Plasticity
  • Patch-Clamp Techniques
  • Social Behavior
  • Synapses
  • Thalamus
  • ras GTPase-Activating Proteins
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Identity

PubMed Central ID

  • PMC3685838

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.0765-13.2013

PubMed ID

  • 23785156
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Additional Document Info

start page

  • 10447

end page

  • 10452

volume

  • 33

issue

  • 25

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