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Midbrain-derived neurotrophins support survival of immature striatal projection neurons

Academic Article
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Overview

authors

  • Baydyuk, M.
  • Xie, Y.
  • Tessarollo, L.
  • Xu, Baoji

publication date

  • February 2013

journal

  • Journal of Neuroscience  Journal

abstract

  • Neuronal death occurs at several stages during embryogenesis and early postnatal development; however, it is unknown how the survival of immature neurons at their origin is regulated before these cells migrate to their final destination. Striatal projection neurons, known as medium-sized spiny neurons (MSNs), in both the direct and indirect pathways are generated in the lateral ganglionic eminence (LGE). Here we report that brain-derived neurotrophic factor and neurotrophin-3 are anterogradely transported from midbrain dopaminergic neurons and support the survival of immature MSNs of the indirect and direct pathways, respectively, in the developing mouse striatum and LGE. These results reveal a novel mode of neurotrophic action in the nervous system by linking neurotrophins to the survival of immature neurons at their origin, while also suggesting that innervating neurons may control the size of their targeting neuronal population in the brain.

subject areas

  • Animals
  • Animals, Newborn
  • Brain Chemistry
  • Brain-Derived Neurotrophic Factor
  • Cell Differentiation
  • Cell Survival
  • Corpus Striatum
  • Dopaminergic Neurons
  • Female
  • Male
  • Mesencephalon
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Nerve Growth Factors
  • Neurons
  • Neurotrophin 3
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Identity

PubMed Central ID

  • PMC3711532

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.3687-12.2013

PubMed ID

  • 23426664
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Additional Document Info

start page

  • 3363

end page

  • 3369

volume

  • 33

issue

  • 8

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