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Ubiquitin ligases and cell cycle control

Academic Article
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Overview

authors

  • Teixeira, L. K.
  • Reed, Steven

publication date

  • 2013

journal

  • Annual Review of Biochemistry  Journal

abstract

  • The ubiquitin-proteasome system plays a pivotal role in the sequence of events leading to cell division known as the cell cycle. Not only does ubiquitin-mediated proteolysis constitute a critical component of the core oscillator that drives the cell cycle in all eukaryotes, it is also central to the mechanisms that ensure that the integrity of the genome is maintained. These functions are primarily carried out by two families of E3 ubiquitin ligases, the Skp/cullin/F-box-containing and anaphase-promoting complex/cyclosome complexes. However, beyond those functions associated with regulation of central cell cycle events, many peripheral cell cycle-related processes rely on ubiquitylation for signaling, homeostasis, and dynamicity, involving additional types of ubiquitin ligases and regulators. We are only beginning to understand the diversity and complexity of this regulation.

subject areas

  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Cell Cycle
  • Cell Cycle Checkpoints
  • Humans
  • Ligases
  • SKP Cullin F-Box Protein Ligases
  • Ubiquitin
  • Ubiquitin-Protein Ligase Complexes
  • Ubiquitin-Protein Ligases
  • Ubiquitination
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Research

keywords

  • APC/C
  • SCF
  • cell cycle checkpoint
  • cyclin-dependent kinase
  • mitosis
  • ubiquitylation
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Identity

International Standard Serial Number (ISSN)

  • 0066-4154 978-0-8243-0882-7

Digital Object Identifier (DOI)

  • 10.1146/annurev-biochem-060410-105307

PubMed ID

  • 23495935
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Additional Document Info

start page

  • 387

end page

  • 414

volume

  • 82

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