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Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability

Academic Article
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Overview

authors

  • Lauffer, B. E. L.
  • Mintzer, R.
  • Fong, R.
  • Mukund, S.
  • Tam, C.
  • Zilberleyb, I.
  • Flicke, B.
  • Ritscher, A.
  • Fedorowicz, G.
  • Vallero, R.
  • Ortwine, D. F.
  • Gunzner, Janet Lorraine
  • Modrusan, Z.
  • Neumann, L.
  • Koth, C. M.
  • Lupardus, P. J.
  • Kaminker, J. S.
  • Heise, C. E.
  • Steiner, P.

publication date

  • 2013

journal

  • Journal of Biological Chemistry  Journal

subject areas

  • Acetylation
  • Benzamides
  • Binding, Competitive
  • Cell Line, Tumor
  • Cell Survival
  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Neoplastic
  • Histone Deacetylase Inhibitors
  • Histones
  • Humans
  • Hydroxamic Acids
  • Inhibitory Concentration 50
  • Kinetics
  • Oligonucleotide Array Sequence Analysis
  • Protein Binding
  • Pyridines
  • Transcription, Genetic
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Identity

PubMed Central ID

  • PMC3772242

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.M113.490706

PubMed ID

  • 23897821
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Additional Document Info

start page

  • 26926

end page

  • 26943

volume

  • 288

issue

  • 37

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