Cu(II)-catalyzed coupling of aromatic C-H bonds with malonates

Academic Article

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Overview

authors

• Wang, H. L.
• Shang, M.
• Sun, S. Z.
• Zhou, Z. L.
• Laforteza, B. N.
• Dai, H. X.
• Yu, Jin-Quan

publication date

• March 2015

journal

• Organic Letters  Journal

abstract

• A new Cu(II)-catalyzed oxidative coupling of arenes with malonates has been developed using an amide-oxazoline directing group. The reaction proceeds via C(sp(2))-H activation and malonate coupling, followed by intramolecular oxidative N-C bond formation. A variety of arenes bearing different substituents are shown to be compatible with this reaction.

subject areas

• Catalysis
• Copper
• Hydrogen Bonding
• Malonates
• Molecular Structure
• Oxazoles
• Oxidative Coupling

Identity

International Standard Serial Number (ISSN)

• 1523-7060

Digital Object Identifier (DOI)

• 10.1021/acs.orglett.5b00193

PubMed ID

• 25695876

Additional Document Info

start page

• 1228

end page

• 1231

volume

• 17

issue

• 5