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Cu(II)-catalyzed coupling of aromatic C-H bonds with malonates

Academic Article
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Overview

authors

  • Wang, H. L.
  • Shang, M.
  • Sun, S. Z.
  • Zhou, Z. L.
  • Laforteza, B. N.
  • Dai, H. X.
  • Yu, Jin-Quan

publication date

  • March 2015

journal

  • Organic Letters  Journal

abstract

  • A new Cu(II)-catalyzed oxidative coupling of arenes with malonates has been developed using an amide-oxazoline directing group. The reaction proceeds via C(sp(2))-H activation and malonate coupling, followed by intramolecular oxidative N-C bond formation. A variety of arenes bearing different substituents are shown to be compatible with this reaction.

subject areas

  • Catalysis
  • Copper
  • Hydrogen Bonding
  • Malonates
  • Molecular Structure
  • Oxazoles
  • Oxidative Coupling
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Identity

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/acs.orglett.5b00193

PubMed ID

  • 25695876
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Additional Document Info

start page

  • 1228

end page

  • 1231

volume

  • 17

issue

  • 5

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