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Lead optimization of antimalarial propafenone analogues

Academic Article
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Overview

authors

  • Lowes, D.
  • Pradhan, A.
  • Iyer, L. V.
  • Parman, T.
  • Gow, J.
  • Zhu, F.
  • Furimsky, A.
  • Lemoff, A.
  • Guiguemde, W. A.
  • Sigal, M.
  • Clark, J. A.
  • Wilson, E.
  • Tang, L.
  • Connelly, M. C.
  • DeRisi, J. L.
  • Kyle, D. E.
  • Mirsalis, J.
  • Guy, Rodney Kiplin

publication date

  • July 2012

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Administration, Oral
  • Animals
  • Antimalarials
  • Chloroquine
  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 CYP2D6 Inhibitors
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Drug Interactions
  • Female
  • HEK293 Cells
  • Hep G2 Cells
  • Humans
  • Malaria
  • Mice
  • Mice, Inbred ICR
  • Microsomes, Liver
  • Parasitemia
  • Plasmodium berghei
  • Propafenone
  • Structure-Activity Relationship
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Identity

PubMed Central ID

  • PMC4408918

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm300286a

PubMed ID

  • 22708838
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Additional Document Info

start page

  • 6087

end page

  • 6093

volume

  • 55

issue

  • 13

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