Lead optimization of antimalarial propafenone analogues

Academic Article

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Overview

authors

• Lowes, D.
• Pradhan, A.
• Iyer, L. V.
• Parman, T.
• Gow, J.
• Zhu, F.
• Furimsky, A.
• Lemoff, A.
• Guiguemde, W. A.
• Sigal, M.
• Clark, J. A.
• Wilson, E.
• Tang, L.
• Connelly, M. C.
• DeRisi, J. L.
• Kyle, D. E.
• Mirsalis, J.
• Guy, Rodney Kiplin

publication date

• July 2012

journal

• Journal of Medicinal Chemistry  Journal

subject areas

• Administration, Oral
• Animals
• Antimalarials
• Chloroquine
• Cytochrome P-450 CYP2D6
• Cytochrome P-450 CYP2D6 Inhibitors
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Drug Interactions
• Female
• HEK293 Cells
• Hep G2 Cells
• Humans
• Malaria
• Mice
• Mice, Inbred ICR
• Microsomes, Liver
• Parasitemia
• Plasmodium berghei
• Propafenone
• Structure-Activity Relationship

Identity

PubMed Central ID

• PMC4408918

International Standard Serial Number (ISSN)

• 0022-2623

Digital Object Identifier (DOI)

• 10.1021/jm300286a

PubMed ID

• 22708838

Additional Document Info

start page

• 6087

end page

• 6093

volume

• 55

issue

• 13