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Structural insights into the design of nonpeptidic isothiazolidinone-containing inhibitors of protein-tyrosine phosphatase 1B

Academic Article
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Overview

authors

  • Ala, P. J.
  • Gonneville, L.
  • Hillman, M.
  • Becker-Pasha, M.
  • Yue, Eddy W
  • Douty, B.
  • Wayland, B.
  • Polam, P.
  • Crawley, M. L.
  • McLaughlin, E.
  • Sparks, R. B.
  • Glass, B.
  • Takvorian, A.
  • Combs, A. P.
  • Burn, T. C.
  • Hollis, G. F.
  • Wynn, R.

publication date

  • December 2006

journal

  • Journal of Biological Chemistry  Journal

subject areas

  • Catalytic Domain
  • Crystallography, X-Ray
  • Drug Design
  • Enzyme Inhibitors
  • Humans
  • Hydrogen Bonding
  • In Vitro Techniques
  • Models, Molecular
  • Protein Conformation
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatases
  • Recombinant Proteins
  • Static Electricity
  • Structure-Activity Relationship
  • Thiazoles
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Identity

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.M607913200

PubMed ID

  • 17028182
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Additional Document Info

start page

  • 38013

end page

  • 38021

volume

  • 281

issue

  • 49

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