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Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin

Academic Article
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Overview

authors

  • Liu, T.
  • Ma, M.
  • Ge, H. M.
  • Yang, C.
  • Cleveland, John
  • Shen, Ben

publication date

  • November 2015

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Antibiotics, Antineoplastic
  • Biological Products
  • Cell Line, Tumor
  • Cell Proliferation
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Humans
  • Lactams
  • Molecular Conformation
  • Streptomyces
  • Structure-Activity Relationship
  • Thiazoles
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Research

keywords

  • Antitumor antibiotic
  • DNA alkylation
  • Leinamycin
  • Metabolic pathway engineering
  • Structure-activity relationship
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Identity

PubMed Central ID

  • PMC4607584

International Standard Serial Number (ISSN)

  • 1464-3405 (Electronic) 0960-894X (Linking)

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2015.05.078

PubMed ID

  • 26071634

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