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Region-specific changes in the microanatomy of single dendritic spines over time might account for selective memory alterations in ageing hAPPsweTg2576 mice, a mouse model for Alzheimer disease

Academic Article
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Overview

authors

  • Middei, S.
  • Restivo, L.
  • Caprioli, A.
  • Aceti, Massimiliano
  • Ammassari-Teule, M.

publication date

  • 2008

journal

  • Neurobiology of Learning and Memory  Journal

abstract

  • Tg2576 mice over-expressing human mutant APP (hAPPswe) show progressive impairments in hippocampal plasticity and episodic memory while fronto-striatal plasticity and procedural memory remain intact. Here we examine the status of synaptic connectivity in the hippocampus and the dorsolateral striatum (DLS) of 3- and 15-month-old Tg2576 and wild-type mice through the analysis of single dendritic spines microanatomy. We found that, in each region, all mice showed a global reduction in the size of spines as a function of age. Ageing mutants, however, exhibited smaller spines with shorter necks on CA1 pyramidal neurons but larger spines with longer necks on DLS spiny neurons compared to their age-matched wild-type controls. Our findings indicate that hippocampal and DLS dendritic spines in hAPPswe mutants undergo a different pattern of morphological changes over time and point to minor alterations in the microanatomy of DLS spines as a compensatory mechanism maintaining procedural abilities in the ageing mutants.

subject areas

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Protein Precursor
  • Animals
  • Brain
  • Corpus Striatum
  • DNA Mutational Analysis
  • Dendritic Spines
  • Disease Models, Animal
  • Frontal Lobe
  • Hippocampus
  • Male
  • Mental Recall
  • Mice
  • Mice, Neurologic Mutants
  • Mice, Transgenic
  • Nerve Net
  • Neuronal Plasticity
  • Neurons
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Research

keywords

  • Alzheimer disease (AD)
  • Tg2576 mice
  • dorsolateral striatum (DLS)
  • hippocampus
  • spine geometry
  • synaptic efficacy
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Identity

International Standard Serial Number (ISSN)

  • 1074-7427

Digital Object Identifier (DOI)

  • 10.1016/j.nlm.2008.04.008

PubMed ID

  • 18515161
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Additional Document Info

start page

  • 467

end page

  • 471

volume

  • 90

issue

  • 2

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