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STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells

Academic Article
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Overview

authors

  • Yap, W. H.
  • Yeoh, E.
  • Tay, A.
  • Brenner, Sydney
  • Venkatesh, B.

publication date

  • August 2005

journal

  • FEBS Letters  Journal

abstract

  • STAT4 is a transcription factor activated in response to IL-12, and is involved in Th1 cell development. The molecular mechanisms controlling the transcription of the STAT4 gene are however, unclear. Sequence comparison of the 5' flanking regions of human, mouse and pufferfish (Fugu rubripes) Stat4 genes revealed a high frequency of Ikaros (Ik) binding elements in all three species. We then investigated the role of Ik binding elements in the human STAT4 promoter using Jurkat T cells. Transactivation, electrophoretic mobility shift assay and RNA interference-mediated gene knockdown experiments revealed that Ik is involved in the regulation of STAT4 in human T cells.

subject areas

  • Animals
  • Base Sequence
  • Binding Sites
  • DNA-Binding Proteins
  • Genome
  • Hematopoiesis
  • Humans
  • Ikaros Transcription Factor
  • Jurkat Cells
  • Mice
  • Molecular Sequence Data
  • Promoter Regions, Genetic
  • RNA Interference
  • STAT4 Transcription Factor
  • T-Lymphocytes
  • Takifugu
  • Trans-Activators
  • Transcription Factors
  • Transcription, Genetic
  • Transcriptional Activation
  • Zinc Fingers
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Research

keywords

  • comparative genomics
  • gene regulation
  • transcription factors
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Identity

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2005.07.018

PubMed ID

  • 16081070
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Additional Document Info

start page

  • 4470

end page

  • 4478

volume

  • 579

issue

  • 20

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