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Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distribution

Academic Article
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  • Research
  • Identity
  • Additional Document Info
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Overview

authors

  • Pfefferkorn, Jeff
  • Litchfield, J.
  • Hutchings, R.
  • Cheng, X.
  • Larsen, S. D.
  • Auerbach, B.
  • Bush, M. R.
  • Lee, C.
  • Erasga, N.
  • Bowles, D. M.
  • Boyles, D. C.
  • Lu, G.
  • Sekerke, C.
  • Askew, V.
  • Hanselman, J. C.
  • Dillon, L.
  • Lin, Z.
  • Robertson, A.
  • Olsen, K.
  • Boustany, C.
  • Atkinson, K.
  • Goosen, T. C.
  • Sahasrabudhe, V.
  • Chupka, J.
  • Duignan, D. B.
  • Feng, B.
  • Scialis, R.
  • Kimoto, E.
  • Bi, Y. A.
  • Lai, Y.
  • El-Kattan, A.
  • Bakker-Arkema, R.
  • Barclay, P.
  • Kindt, E.
  • Le, V.
  • Mandema, J. W.
  • Milad, M.
  • Tait, B. D.
  • Kennedy, R.
  • Trivedi, B. K.
  • Kowala, M.

publication date

  • May 2011

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Animals
  • Cells, Cultured
  • Dogs
  • Dose-Response Relationship, Drug
  • Drug Discovery
  • Hepatocytes
  • Heptanoic Acids
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Hypercholesterolemia
  • Imidazoles
  • Inhibitory Concentration 50
  • Liver
  • Molecular Structure
  • Pyrazoles
  • Rats
  • Tissue Distribution
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Research

keywords

  • HMG-CoA reductase inhibitor
  • Hepatoselective
  • Hypercholesterolemia
  • Liver selective
  • Statin
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2010.11.103

PubMed ID

  • 21183342
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Additional Document Info

start page

  • 2725

end page

  • 2731

volume

  • 21

issue

  • 9

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