Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors

Academic Article

• Overview
• Research
• Identity
• Additional Document Info
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Overview

authors

• Siu, T.
• Liang, J.
• Arruda, J.
• Li, Yiwei
• Jones, R. E.
• Defeo-Jones, D.
• Barnett, S. F.
• Robinson, R. G.

publication date

• July 2008

journal

• Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

• Allosteric Site
• Chemistry, Pharmaceutical
• Chemistry, Physical
• Drug Design
• Humans
• Inhibitory Concentration 50
• Models, Chemical
• Phosphorylation
• Piperazines
• Protein Kinase Inhibitors
• Proto-Oncogene Proteins c-akt
• Solvents
• Stereoisomerism
• Structure-Activity Relationship

Research

keywords

• Akt
• allosteric
• cell active
• kinase

Identity

International Standard Serial Number (ISSN)

• 0960-894X

Digital Object Identifier (DOI)

• 10.1016/j.bmcl.2008.05.085

PubMed ID

• 18539456

Additional Document Info

start page

• 4186

end page

• 4190

volume

• 18

issue

• 14