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Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors

Academic Article
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  • Research
  • Identity
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Overview

authors

  • Siu, T.
  • Liang, J.
  • Arruda, J.
  • Li, Yiwei
  • Jones, R. E.
  • Defeo-Jones, D.
  • Barnett, S. F.
  • Robinson, R. G.

publication date

  • July 2008

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Allosteric Site
  • Chemistry, Pharmaceutical
  • Chemistry, Physical
  • Drug Design
  • Humans
  • Inhibitory Concentration 50
  • Models, Chemical
  • Phosphorylation
  • Piperazines
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins c-akt
  • Solvents
  • Stereoisomerism
  • Structure-Activity Relationship
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Research

keywords

  • Akt
  • allosteric
  • cell active
  • kinase
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2008.05.085

PubMed ID

  • 18539456
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Additional Document Info

start page

  • 4186

end page

  • 4190

volume

  • 18

issue

  • 14

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