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Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Academic Article
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Overview

authors

  • Koenig, P. A.
  • Das, H.
  • Liu, H. J.
  • Kummerer, B. M.
  • Gohr, F. N.
  • Jenster, L. M.
  • Schiffelers, L. D. J.
  • Tesfamariam, Y. M.
  • Uchima, M.
  • Wuerth, J. D.
  • Gatterdam, K.
  • Ruetalo, N.
  • Christensen, M. H.
  • Fandrey, C. I.
  • Normann, S.
  • Todtmann, J. M. P.
  • Pritzl, S.
  • Hanke, L.
  • Boos, J.
  • Yuan, M.
  • Zhu, X. Y.
  • Schmid-Burgk, J. L.
  • Kato, H.
  • Schindler, M.
  • Wilson, Ian
  • Geyer, M.
  • Ludwig, K. U.
  • Hallberg, B. M.
  • Wu, N. C.
  • Schmidt, F. I.

publication date

  • January 12, 2021

journal

  • Science  Journal

subject areas

  • Amino Acid Substitution
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Antibody Affinity
  • Antigens, Viral
  • Binding Sites, Antibody
  • COVID-19
  • Cell Line
  • Cryoelectron Microscopy
  • Epitopes
  • Humans
  • Membrane Fusion
  • Mutation
  • Protein Binding
  • Protein Conformation
  • Protein Domains
  • Receptors, Coronavirus
  • SARS-CoV-2
  • Single-Domain Antibodies
  • Spike Glycoprotein, Coronavirus
  • Virus Replication
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Identity

PubMed Central ID

  • PMC7932109

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.abe6230

PubMed ID

  • 33436526
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Additional Document Info

volume

  • 371

issue

  • 6530

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