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A new class of allosteric HIV-1 integrase inhibitors identified by crystallographic fragment screening of the catalytic core domain

Academic Article
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Overview

authors

  • Patel, D.
  • Antwi, J.
  • Koneru, P. C.
  • Serrao, E.
  • Forli, Stefano
  • Kessl, J. J.
  • Feng, L.
  • Deng, N. J.
  • Levy, R. M.
  • Fuchs, J. R.
  • Olson, Arthur
  • Engelman, A. N.
  • Bauman, J. D.
  • Kvaratskhelia, M.
  • Arnold, E.

publication date

  • November 2016

journal

  • Journal of Biological Chemistry  Journal
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Research

keywords

  • HIV-1
  • HIV-1 integrase
  • X-ray crystallography
  • allosteric inhibitor
  • drug discovery
  • drug screening
  • fragment screening
  • human immunodeficiency virus (HIV)
  • integrase
  • medicinal chemistry
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Identity

PubMed Central ID

  • PMC5095411

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.M116.753384

PubMed ID

  • 27645997
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Additional Document Info

start page

  • 23569

end page

  • 23577

volume

  • 291

issue

  • 45

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