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Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor alpha 1

Academic Article
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Overview

authors

  • Redpath, N. T.
  • Xu, Y.
  • Wilson, N. J.
  • Fabri, L. J.
  • Baca, Manuel
  • Andrews, A. E.
  • Braley, H.
  • Lu, P.
  • Ireland, C.
  • Ernst, R. E.
  • Woods, A.
  • Forrest, G.
  • An, Z.
  • Zaller, D. M.
  • Strohl, W. R.
  • Luo, C. S.
  • Czabotar, P. E.
  • Garrett, T. P. J.
  • Hilton, D. J.
  • Nash, A. D.
  • Zhang, J. G.
  • Nicola, N. A.

publication date

  • April 2013

journal

  • Biochemical Journal  Journal

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Antibodies, Neutralizing
  • Binding Sites
  • Crystallography, X-Ray
  • Dimerization
  • Epitopes
  • Humans
  • Immunoglobulin Fab Fragments
  • Interleukin-13
  • Interleukin-13 Receptor alpha1 Subunit
  • Interleukin-4
  • Leucine
  • Mice
  • Mice, Transgenic
  • Protein Structure, Tertiary
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Research

keywords

  • T(H)2 immune response
  • antibody
  • asthma
  • interleukin-4
  • interleuldn-13
  • monoclonal
  • receptor
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Identity

International Standard Serial Number (ISSN)

  • 0264-6021

Digital Object Identifier (DOI)

  • 10.1042/bj20121819

PubMed ID

  • 23384096
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Additional Document Info

start page

  • 165

end page

  • 175

volume

  • 451

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