Structure-based design of thienobenzoxepin inhibitors of PI3-kinase

Academic Article

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• Research
• Identity
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Overview

authors

• Staben, S. T.
• Siu, M.
• Goldsmith, R.
• Olivero, A. G.
• Do, S.
• Burdick, D. J.
• Heffron, T. P.
• Dotson, J.
• Sutherlin, D. P.
• Zhu, B. Y.
• Tsui, Vickie
• Le, H.
• Lee, L.
• Lesnick, J.
• Lewis, C.
• Murray, J. M.
• Nonomiya, J.
• Pang, J.
• Prior, W. W.
• Salphati, L.
• Rouge, L.
• Sampath, D.
• Sideris, S.
• Wiesmann, C.
• Wu, P.

publication date

• 2011

journal

• Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

• Animals
• Benzoxepins
• Cell Line, Tumor
• Crystallography, X-Ray
• Drug Design
• Enzyme Activation
• Enzyme Inhibitors
• Humans
• Inhibitory Concentration 50
• Mice
• Molecular Structure
• Phosphatidylinositol 3-Kinases
• Structure-Activity Relationship
• Thiophenes
• Xenograft Model Antitumor Assays

Research

keywords

• PI3-kinase
• Structure-based design

Identity

International Standard Serial Number (ISSN)

• 0960-894X

Digital Object Identifier (DOI)

• 10.1016/j.bmcl.2011.04.124

PubMed ID

• 21636270

Additional Document Info

start page

• 4054

end page

• 4058

volume

• 21

issue

• 13