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Structure-based design of thienobenzoxepin inhibitors of PI3-kinase

Academic Article
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  • Research
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Overview

authors

  • Staben, S. T.
  • Siu, M.
  • Goldsmith, R.
  • Olivero, A. G.
  • Do, S.
  • Burdick, D. J.
  • Heffron, T. P.
  • Dotson, J.
  • Sutherlin, D. P.
  • Zhu, B. Y.
  • Tsui, Vickie
  • Le, H.
  • Lee, L.
  • Lesnick, J.
  • Lewis, C.
  • Murray, J. M.
  • Nonomiya, J.
  • Pang, J.
  • Prior, W. W.
  • Salphati, L.
  • Rouge, L.
  • Sampath, D.
  • Sideris, S.
  • Wiesmann, C.
  • Wu, P.

publication date

  • July 2011

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Animals
  • Benzoxepins
  • Cell Line, Tumor
  • Crystallography, X-Ray
  • Drug Design
  • Enzyme Activation
  • Enzyme Inhibitors
  • Humans
  • Inhibitory Concentration 50
  • Mice
  • Molecular Structure
  • Phosphatidylinositol 3-Kinases
  • Structure-Activity Relationship
  • Thiophenes
  • Xenograft Model Antitumor Assays
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Research

keywords

  • PI3-kinase
  • Structure-based design
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2011.04.124

PubMed ID

  • 21636270
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Additional Document Info

start page

  • 4054

end page

  • 4058

volume

  • 21

issue

  • 13

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