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Cycloadditions of noncomplementary substituted 1,2,3-triazines

Academic Article
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Overview

related to degree

  • Glinkerman, Christopher, Ph.D. in Chemistry, Scripps Research 2013 - 2018
  • Anderson, Erin, Ph.D. in Organic Chemistry, Scripps Research 2007 - 2013

authors

  • Anderson, Erin
  • Duerfeldt, A. S.
  • Zhu, K.
  • Glinkerman, Christopher
  • Boger, Dale

publication date

  • October 2014

journal

  • Organic Letters  Journal

abstract

  • The scope of the [4 + 2] cycloaddition reactions of substituted 1,2,3-triazines, bearing noncomplementary substitution with electron-withdrawing groups at C4 and/or C6, is described. The studies define key electronic and steric effects of substituents impacting the reactivity, mode (C4/N1 vs C5/N2), and regioselectivity of the cycloaddition reactions of 1,2,3-triazines with amidines, enamines, and ynamines, providing access to highly functionalized heterocycles.

subject areas

  • Cycloaddition Reaction
  • Molecular Structure
  • Stereoisomerism
  • Triazines
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Identity

PubMed Central ID

  • PMC4184932

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol502436n

PubMed ID

  • 25222918
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Additional Document Info

start page

  • 5084

end page

  • 5087

volume

  • 16

issue

  • 19

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