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Inability of serum myocyte death markers to predict acute cardiac allograft rejection

Academic Article
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Overview

authors

  • Wang, C. W.
  • Steinhubl, Steven
  • Castellani, W. J.
  • VanLente, F.
  • Miller, D. P.
  • James, K. B.
  • Young, J. B.

publication date

  • December 1996

journal

  • Transplantation  Journal

abstract

  • Acute cardiac rejection involves myocyte necrosis. Hence, markers of myocyte death may be useful in diagnosing rejection. Creatine kinase MB, MB isoforms, and troponins I and T were measured in 186 patients undergoing 365 endomyocardial biopsies. No differences were noted with rejection (rejectors vs. nonrejectors: CK=63.8 U/L and 86.6 U/L, P=0.0881; CK MB=2.04 ng/ml and 2.06 ng/ml, P=0.949; troponin T=0.134 ng/ml and 0.0881 ng/ml, P=0.374; troponin I=0.216 ng/ml and 0.707 ng/ml, P=0.357). The time course of troponins T and I levels in rejectors and nonrejectors do not differ with both groups having early elevations. Markers of myocyte death are inadequate predictors of acute rejection in cardiac allografts. The time course of troponins T and I suggests a possible role as prognostic indicators of outcome.

subject areas

  • Acute Disease
  • Biomarkers
  • Cell Death
  • Clinical Enzyme Tests
  • Creatine Kinase
  • Graft Rejection
  • Heart Transplantation
  • Humans
  • Isoenzymes
  • Muscle, Smooth
  • Troponin
  • Troponin I
  • Troponin T
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Identity

International Standard Serial Number (ISSN)

  • 0041-1337

Digital Object Identifier (DOI)

  • 10.1097/00007890-199612270-00046

PubMed ID

  • 8990392
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Additional Document Info

start page

  • 1938

end page

  • 1941

volume

  • 62

issue

  • 12

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